½üÈÕ£¬Ò½Ñ§ÔºÕÅ´¨½ÌÊÚÍŶÓÔÚÒ©¼ÁѧÁìÓò¹ú¼Ê¶¥¼¶Ñ§ÊõÆÚ¿¯¡¶Journal of Controlled release¡·(¹ú¼Ê½ÚÔ쿪ÊÍѧ»áµÄ¹Ù·½Ñ§ÊõÔÓÖ¾£¬Ò©ÎïµÝËÍÁìÓòTopÆÚ¿¯£¬ÖпÆÔº1ÇøTOPÆÚ¿¯£¬IF=11.467)ÉÏ°ä·¢ÌâΪ¡°Recent advances in biomimetic nanodelivery systems: New brain-targeting strategies¡±µÄ×ÛÊöÂÛÎÄ¡£
ҽѧԺ2021¼¶Ò©Ñ§×¨ÒµË¶Ê¿ÉúÁξþΪ±¾ÎĵÚÒ»×÷Õߣ¬Ò½Ñ§Ôº2020¼¶ÐÂÒ©ÎïÐÂ×ÊÁÏרҵ²©Ê¿ÉúÀõÒâºÍˮʦ¾üÒ½´óѧҩ¼Á½ÌÑÐÊÒ·®Àò¸±½ÌÊÚΪ±¾ÎĵĹ²Í¬µÚÒ»×÷Õߣ¬Ð±¦GGҽѧԺΪÂÛÎĵÚһʵÏÖµ¥Ôª¡£Ë®Ê¦¾üÒ½´óѧҩ¼Á½ÌÑÐÊÒ³Ө½ÌÊÚΪͨѶ×÷Õߣ¬ÕÅ´¨½ÌÊÚÍŶÓÇàÀÏ´óʦÍõÍ¥·¼²©Ê¿¡¢Ë®Ê¦¾üÒ½´óѧ·À»¯Ò½Ñ§½ÌÑÐÊÒФ¿½ÌÊÚ¡¢ÃÀ¹úÊ¥Ô¼º²´óѧ³ÂÕÜÉú½ÌÊÚΪ¹²Í¬Í¨Ñ¶×÷Õß¡£¸ÃÏî×êÑй¤×÷»ñµÃ¹ú¶È³Á´óÐÂÒ©´´ÔìרÏî¡¢¹ú¶ÈÌìÈ»¿Æѧ»ù½ð¡¢ÉϺ£ÊÐÌìÈ»¿Æѧ»ù½ðµÄÖ§³Ö¡£
ÄÔ²¿¼²²¡ÒÔÆä¸ß·¢²¡ÂʺÍéæÃüÂÊÑϳÁÍþв×ÅÈËÀཡȫ¡£Ò©ÎïÒ½ÖÎÄÔ²¿¼²²¡Ãæ¶ÔµÄÖØÒªÌôÕ½ÊÇ´óÄԵĽṹ¸öÐÔÒÔ¼°ÎÞ·¨Í¨¹ýѪÄÔ·®À飨BBB£©×ªÔËÒ©ÎʵÏÖÓÐЧµÄÒ©ÎïµÝËÍÒÔÌṩÁîÈËÖÐÒâµÄÒ½ÖÎÁ˾ÖÊÇÄ¿Ç°Ò½ÖÎÄÔ²¿¼²²¡µÄÓÐЧ·½Ê½Ö®Ò»¡£·ÂÉúÄÉÃ×µÝËÍϵͳΪ¿ª·¢°²È«ÓÐЧµÄÁÆ·¨ÌṩÁËеĻúÓö£¬ÔÚÒ½ÖÎÄÔ²¿¼²²¡·½ÃæÏÔʾ³öÇ°ËùδÓеÄDZÁ¦£¬µ«ÏÖÓÐÎļþ¶Ô·ÖÆçÀàÐ͵ķÂÉúÄÉÃ×ÔØÌå¿çBBBÒ©ÎïµÝËÍϵͳ¿Ø²»×ãÍêÕûµÄÁìµ¼ÐÔ×ÛÊö¡£±¾×ÛÊöÂÛÎĶԷÂÉúÄÉÃ×µÝËÍϵͳÔÚÄÔ²¿¼²²¡µÄÀûÓýøÐÐÁËϵͳ·ÖÎö£¬²¢¶ÔÆäÇ°ÑؽøÕ¹½øÐÐÁËÏ꾡ÆÀÊö£¬ÒÔÆÚΪÕë¶ÔÁÙ´²×ª»¯µÄ·ÂÉúÄÉÃ×µÝËÍϵͳµÄÉè¼Æ¡¢¹¹½¨ºÍת»¯Ìṩ¸ü¶à²Î¿¼¡£
ÏÖÓеķÂÉúÁÆ·¨¿É·ÖΪÒÔϼ¸Àࣺ£¨1£©ÌìÈ»ÆðÔ´µÄÄÚÔ´ÐÔÎïÖÊ£¬´«Í³ÉÏÊÇ´ÓÉúÎïÌå»ò΢ÉúÎïÖÐÌáÈ¡ºÍ´¿»¯µÄÄÚÔ´ÐÔÎïÖÊ£¬ÀýÈç°ü¹üϸ°û¡¢²¡¶¾¡¢Ï¸¾úºÍϸ°û±íÄÒÅÝ£»£¨2£©ºÏ³ÉÄÚÔ´ÐÔÎïÖÊ£¬ÖØҪͨ¹ý¿Ï¶¨µÄ¼¼Êõ¼¿Á©£¬Ìå±íºÏ³É¿É·ÂÕÕÄÚÔ´ÐÔÎïÖʵĻ¯ºÏÎÈçÁ×Ö¬¡¢µ¨¹Ì´¼µÈ£»(3)·ÂÕÕ²¡Àí»·¾³µÄÒ©ÎïµÝËÍϵͳ£¬Í¨¹ý·ÂÕÕÌض¨¼²²¡µÄÌض¨²¡ÀíÇ°ÌáʵÏÖÒ©ÎïµÄ°ÐÏò¿ªÊÍ¡£ÉÏÊöÏȽøµÄ·ÂÉúÄÉÃ×µÝËÍϵͳÔÚÒ½ÖÎÄÔ²¿¼²²¡·½ÃæÏÔʾ³öºÜ¶àÓÅÊƺÍÁÙ´²Ç°ÀûÓá£Ó봫ͳµÄÄÉÃ×ÁÆ·¨Ïà±È£¬·ÂÉúÄÉÃ×µÝËÍϵͳӵÓÐÉúÎïÏàÈÝÐԺͿɽµ½âÐÔ£¬¿ÉÈ·±£Æä˳Àûͨ¹ýѪÄÔ·®Àé´ïµ½²¡Ôî¡£´Ë±í£¬·ÂÉúÄÉÃ×µÝËÍϵͳͨ¹ýѪÄÔ·®ÀéʵÏÖ¡°¶þ´Î°ÐÏò¡±ºó£¬Äܹ»½øÒ»²½°ÐÏò·ÖÆ粡Àí»·¾³ÏµÄÌض¨Ï¸°ûÆ÷£¬´Ó¶ø¶ÔÌض¨¼²²¡²ûÑï¸ßЧµÄ¶à°Ðµã×÷Óá£
½üÄêÀ´£¬ÕÅ´¨½ÌÊÚÍŶÓÔÚÐÄÄÔѪ¹Üϵͳ¼²²¡»ù´¡×êÑÐÓëÐÂÒ©³É¾Íת»¯»ñµÃÁËÖî¶à³É¾Í¡£ÓйØÂÛÎÄ°ä·¢ÔÚBioorganic Chemistry, 2023, 131, 106283;Chemical Biology and Drug Design, 2023,101(2):408-421;Acta Pharmacologica Sinica, 2023, 44(1)£º44-57£»Molecular Pharmaceutics, 2022, 19(9): 3026¨C3041;Acta Pharmacologica Sinica,2019, 40(12): 1513-1522µÈÆÚ¿¯ÉÏ£»ÓйØÐÂÒ©ÒÑ»ñÅúÁÙ´²ÅúÎÄ£¬Ä¿Ç°ÔÚ·¢Õ¹ÓйØÁÙ´²×êÑС£
ÔÎÄÁ´½Ó£ºhttps://www.sciencedirect.com/science/article/pii/S016836592300322X#s0120
